Our mission is to extend multi-isotope imaging mass spectrometry – or MIMS – to new areas of biology and biomedical research, including with human translational studies conducted at the Brigham and Women’s Hospital and collaborating medical centers.

Measurement of cell division in the injured heart.

MIMS merges the use of innocuous stable isotope tracer methodology with a new form of high-resolution ion microscope and secondary ion mass spectrometer. Through quantification of atomic composition in volumes much smaller than a cubic micron, MIMS tracks metabolic processes into suborganelle domains.

3D Stereocilia
3D rendering of quantified protein turnover in a mouse stereocilia bundle. Volume measued is 8x8x2 um.

In 2016 the BWH Center for NanoImaging emerged from the NIH sponsored National Resource for Imaging Mass Spectrometry (NRIMS), where MIMS was pioneered using the prototype instrument of what was to become the NanoSIMS 50L instrument. The Center emphasizes collaborative science and we have a range of models to partner with internal and external investigators.