Matthew L. Steinhauser, MD - Director
Matthew completed his undergraduate and medical degrees at the University of Michigan in Ann Arbor, where he studied the cytokine and chemokine networks that regulate acute and chronic inflammation in the laboratory of Dr. Steven Kunkel. He trained in Internal Medicine and was a Chief Resident at Columbia University Medical Center. After moving to Boston in 2006, he completed a Cardiovascular Clinical Fellowship at the Brigham and Women’s Hospital, followed by postdoctoral research training in the laboratory of Dr. Richard Lee, during which time he also became a mentee and collaborator of Dr. Lechene gaining expertise in MIMS. Matthew was a key collaborator on a range of projects involving MIMS during his post-doctoral training and early faculty appointment, including studies of intestinal stem cell division, mammalian heart regeneration, and adipocyte turnover. He has also led the effort to translate MIMS to human studies. He started his laboratory in the Brigham and Women’s Hospital Division of Genetics in 2013 and became director of the renamed Center for NanoImaging in 2015.
Claude P. Lechene, MD - Immediate Past Director
Dr. Lechene studied Mathematics and Chemistry followed by Medicine at the University of Paris. After additional research as an Investigator in the Biology Department at the Atomic Energy Commission (CEA), Center for Nuclear Studies, Saclay, France, he moved to the University of Sherbrooke, Canada as a Professor of Physiology. He then moved to Harvard Medical School in 1971. Over the years, Dr. Lechene directed several NIH-funded National Resources, including the National Biotechnology Resource in Electron Probe Microanalysis, the National Electron Probe Resource for Analysis of Cells, and finally the National Resource for Imaging Mass Spectrometry (NRIMS). The effort in developing MIMS as part of NRIMS grew out of a long-standing collaboration with Dr. Georges Slodzian, a founding father of secondary ion mass spectrometry. The initial development of MIMS was performed with the prototype of what became the commercial NanoSims instrument. The early development of MIMS resulted in a series of landmark papers ranging from the demonstration of nitrogen fixation in individual microbes, quantitative measurement of protein turnover in the stereocilia of the inner ear, disproving the immortal strand hypothesis in the small intestine, advancing our understanding of the mammalian heart's capacity for self-renewal, and finally opening the door to human MIMS studies. After 15 years as Director of NRIMS, Dr. Lechene passed on leadership of the Center to Dr. Matthew Steinhauser, who he helped train. Dr. Lechene is a Fellow of the American Association for the Advancement of Science and directs a range of active research projects involving MIMS.
Christelle Guillermier - Instructor of Medicine
Dr. Guillermier is an instrumental/experimental physicist, who received her Ph.D. from the Institute de Physique Nucleaire de Lyon, France. During a series of post-doctoral fellowships, she received training in Secondary Ion Mass Spectrometry, including the design and implementation of new instrumentation and research in fundamental SIMS, geo- and cosmo-chemistry, and material sciences . In 2010, she joined NRIMS, where in addition to operating the Center's two NanoSIMS instrument, she has leveraged her expertise to develop new analytical methods for the exploration of biological samples.
J. Collin Poczatek - Laboratory Manager
Collin studied mathematics at the University of Chicago, where he received a BA degree. After graduate coursework in algebra and discrete dynamics at Boston University, he joined NRIMS as a software developer. He has since developed a range of expertise in the operation and maintenance of the NanoSIMS instruments, development and maintenance of the OpenMIMS software, architecting IT infrastructure, and participation in experimental design and conduct of cell biological experiments conducted in the lab.