High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry.

Citation:

Lechene C, Hillion F, McMahon G, Benson D, Kleinfeld AM, Kampf PJ, Distel D, Luyten Y, Bonventre J, Hentschel D, et al. High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry. Journal of biology [Internet]. 2006;5 (6) :20.

Date Published:

jan

Abstract:

Secondary-ion mass spectrometry (SIMS) is an important tool for investigating isotopic composition in the chemical and materials sciences, but its use in biology has been limited by technical considerations. Multi-isotope imaging mass spectrometry (MIMS), which combines a new generation of SIMS instrument with sophisticated ion optics, labeling with stable isotopes, and quantitative image-analysis software, was developed to study biological materials.

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